Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease.

Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3 mice showed an enhanced nigro-striatal damage and microglial activation in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Availability and quality assessment of Clinical Practice Guidelines on orthoplastic surgery treatment of open fractures of the lower limb using AGREE II tool: A systematic review.

Introduction: Orthoplastic surgery, which combines orthopedic and plastic surgery principles, plays a crucial role in the treatment of open fractures of the lower limb. Clinical Practice Guidelines (CPGs) are valuable tools for standardizing and improving patient care.

Objective: To assess the availability and quality of international CPGs for orthoplastic treatment of open fractures of the lower limb.

Albumin orchestrates a natural host defense mechanism against mucormycosis.

Mucormycosis is an emerging, life-threatening human infection caused by fungi of the order Mucorales. Metabolic disorders uniquely predispose an ever-expanding group of patients to mucormycosis via poorly understood mechanisms. Therefore, it is highly likely that uncharacterized host metabolic effectors confer protective immunity against mucormycosis.

I am where I believe my body is: The interplay between body spatial prediction and body ownership.

Body ownership refers to the feeling that the body belongs to oneself. This study explores how our ability to predict our body's location in space influences feelings of ownership and disownership towards it, comparing two illusion techniques: the virtual Rubber Hand Illusion (vRHI) and the first-person perspective Full-Body Illusion (1pp-FBI). Participants were exposed to each illusion, where they observed a virtual body aligned or misaligned with their own.

Rare Spinocerebellar Ataxia Types in Canada: A Case Series and Review of the Literature.

Background: There is limited information on rare spinocerebellar ataxia (SCA) variants, particularly in the Canadian population. This study aimed to describe the demographic and clinical features of uncommon SCA subtypes in Canada and compare them with international data.

Methods: We conducted a case series and literature review of adult patients with rare SCA subtypes, including SCA5, SCA7, SCA12, SCA14, SCA15, SCA28, SCA34, SCA35 and SCA36.