The correlation of genetic markers with anatomoclinical and histopathological forms in Hirschsprung's disease.

Hirschsprung's disease is a birth defect that affects about one out of 5000 newborns. It is one of the most common causes of intestinal obstruction at the babies. The objectives of this study are to evaluate the characteristics of Hirschsprung's disease in Dobrogea area, test of genetic markers in families and single cases, estimate the value of the test in the diagnosis and for evolution.

Comparative microscopic study of the ovarian blood vessels.

The present study puts forth the morphometric analysis of modifications that occur in the ovarian structures (stroma, parenchyma, blood vessels) before and after menopause onset. Our study was performed on 30 human ovary specimens from patients with no history of genital pathology that were split in two groups (15 ovaries harvested from fertile women and 15 ovaries harvested from women at menopause). The specimens were processed following the classic histological technique of paraffin embedding and stained using Hematoxylin-Eosin technique and trichromic Goldner-Szeckelly technique.