Publications by authors named "V Briz"
Article Synopsis
- - The study investigated the effect of obesity on the likelihood of achieving return of spontaneous circulation (ROSC) in patients who experienced out-of-hospital cardiac arrests (OHCA), considering differences between sexes.
- - A large cohort of 33,636 OHCA patients in Poland was analyzed, revealing that while univariate analysis suggested obesity may reduce the odds of ROSC, multivariate analysis showed no significant impact after adjusting for other factors.
- - Key factors influencing ROSC included initial heart rhythms like ventricular fibrillation, the location of the cardiac arrest, and age, with specific differences noted between male and female patients.
Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I, MDA5 and LGP2, recognize viral RNA to mount an antiviral interferon (IFN) response RLRs share three different protein domains: C-terminal domain, DExD/H box RNA helicase domain, and an N-terminal domain with two tandem repeats (CARDs). LGP2 lacks tandem CARD and is not able to induce an IFN response. However, LGP2 positively enhances MDA5 and negatively regulates RIG-I signaling.
View Article and Find Full Text PDFPurpose: Globally, it is estimated that 1.0 million individuals are newly infected by Hepatitis C virus (HCV) every year, and nearly 50 million people live with a chronic infection, according to World Health Organization. To overcome underdiagnosis of HCV infection among hard-to-reach populations, it is essential to develop new rapid and easy-to-use molecular diagnostic systems.
View Article and Find Full Text PDFArticle Synopsis
- - Niemann-Pick disease Type C (NPC) is linked to mutations in the NPC1 protein that disrupt cholesterol transport, leading to lipid buildup and psychiatric problems.
- - In an NPC mouse model, researchers discovered that mGluR (metabotropic glutamate receptors) accumulate abnormally inside cells, affecting their function and leading to changes in long-term depression (a form of synaptic plasticity).
- - Treatment with the mGluR antagonist CTEP lowered mGluR-related issues and improved psychiatric symptoms, suggesting alterations in mGluR play a role in NPC and offering potential new therapies for affected individuals.
Article Synopsis
- About 10% of people with HIV experience low-level viremia (LLV) despite antiretroviral therapy, yet the causes and impacts of this condition remain largely unknown, especially within specific viral load ranges and modern treatment methods.
- The study observed 81 participants, comparing those with LLV to those with suppressed viremia and non-HIV controls, focusing on immune response characteristics and inflammation markers through advanced flow cytometry and immunoassays.
- Findings indicated that LLV individuals exhibit greater T-cell activation and senescence, along with a decline in certain immune cell types, which could impair their ability to control HIV and harm long-term immune memory.