Reconciling Pollen Limitation Theories: Insights From Temperate Oak Masting.

Pollen limitation has a considerable influence on forest masting, the highly variable and synchronised seed production, on which forest regeneration and ecosystem dynamics largely rely. Depending on the various mechanisms possibly involved in pollen limitation, the consequences of climate change on masting could be very different. These mechanisms were investigated in 10 oak populations along a climatic gradient using surveys of airborne pollen and fruiting rate as a proxy of pollen limitation.

Preclinical Safety Evaluation of Etripamil Nasal Spray in Cynomolgus Macaques () to Assess for Safety in Patients With Paroxysmal Supraventricular Tachycardia.

Etripamil is a calcium channel blocker currently in Phase 3 trials for the treatment of paroxysmal supraventricular tachycardia (PSVT). Systemic and local toxicity following once-weekly intranasal administration of etripamil was evaluated in cynomolgus macaques to support clinical development. Groups of animals (N = 8, 4 males and 4 females) were administered etripamil into the left nostril weekly at dose levels of 0 (vehicle), 1.

CPA-ready femtosecond pulses at 1 MHz from a custom recycled output Mamyshev oscillator.

A cost-effective fiber laser architecture is introduced in which the output seed pulse is stretched and then returned in the oscillator for an additional single-pass amplification without spectral broadening. It is implemented in an all-PM-fiber configuration based on a Mamyshev oscillator with a low repetition rate of 1 MHz. It features a linear oscillator bounded by two offset chirped fiber Bragg gratings accompanied by a third one acting as a pulse recycling filter.