Publications by authors named "V Bohr"
Introduction: During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA and NR are considered safe dietary supplements, it is equally important to understand their function in normal cells and in disease states.
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- * Results show that centenarians with better physical capabilities have more mtDNA and lower mitochondrial dysfunction compared to those with disabilities.
- * Additionally, correlations were found between grip strength, mtDNA copy number, and DNA repair enzyme activity, indicating that maintaining mitochondrial function might help preserve physical abilities in very old age.
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- * The study investigated NR's effects using various models that simulate oxidative stress, aging, and AD, focusing on neuronal survival and the complex interactions of reactive species.
- * Findings reveal that NR treatment affects specific protein networks related to energy metabolism and neurotransmitter regulation, suggesting potential pathways for modifying the disease processes in AD.
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- FOXO transcription factors influence aging and longevity by regulating specific target genes, one of which is OSER1, a gene that extends lifespan in various species like silkworms, nematodes, and flies when overexpressed.* -
- Overexpression of OSER1 enhances resistance to oxidative stress, starvation, and heat shock in flies, while its depletion increases vulnerability to these stressors and shortens lifespan; similar effects are observed in C. elegans and silkworms.* -
- OSER1 is linked to important biological processes such as oxidative stress response and mitochondrial health, suggesting that it may play a role in healthy aging and even human longevity, as indicated by genetic studies.*
Article Synopsis
- Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by the buildup of amyloid plaques and tau tangles, leading to memory loss and brain damage.
- Researchers used a C. elegans model to explore the role of DNA glycosylases in AD progression, discovering that certain genetic modifications improved mitochondrial health, lifespan, and cognitive function in nematodes with tau pathology.
- The study highlights the importance of the DNA glycosylase NTH-1, showing it has additional functions beyond its enzyme activity, suggesting it could be a potential target for therapeutic strategies against tau-related diseases.