Natrium, potassium, cholesterol and total free 11-hydroxycorticosteroids variations in thymectomized and thymic extract treated rats.

The authors investigated the effect of thymectomy and TP2 thymic polypeptide extract administration on total, esterified and free cholesterol in the plasma and the adrenals, as well as on plasma Na and K and plasma free total 11-hydroxycorticosteroids. The results showed that total, esterified and free cholesterol decrease in the adrenals by 23.20%, 28.

The in vitro effect of a thymic polypeptidic extract on the function of T-cells and macrophages.

A thymic polypeptidic extract with a molecular weight of under 10,000 daltons was used in in vitro experiments to test its effect on the E-rosetting reaction of the T-total and T-helper lymphocytes from the peripheral blood of patients with thyroid cancer, Cushing's syndrome and others, as well as from healthy persons. The effect of the extract on peritoneal macrophages phagocytosis from both irradiated and normal rats was also tested in vitro. It was found that in healthy persons the E-total rosettes count did not change under the influence of the thymic extract, whereas the E-helper rosettes count increased up to 21% in 4 of the 10 subjects.

The effect of some thymic extracts on antibody formation in rats and mice.

The influence of some thymic extracts TP1 and TP2 on the number of hemolytic plaque-forming cells (PFC) in the mouse spleen, on the titre of serum antibodies, S-typhy antiflagelar agglutinins and anti-influenza antibodies, was investigated. The results have shown that the hemolytic plaque-forming cells in the mouse spleen increase significantly, 2.3 times under the influence of the TP2 thymic extract in RAP mice inoculated with sheep red cells.

The phagocytosis function and the antibody reactivity in the thymectomized and thymectomized-irradiated adult rats.

The authors have investigated the influence of the thymus on peritoneal macrophages phagocytosis and antiflagellar agglutinin serum antibodies to "H" Salmonella typhi in the adult rat with diminished immunologic potential. The results show that the immune reactions diminish in intensity in the thymectomized animal. The immune reactions are also diminished in the thymectomized animal exposed to radiation as compared to control irradiated but non-thymectomized.