Publications by authors named "V Bhudhisawasdi"
Glyphosate [N-(phosphonomethyl) glycine], a systemic herbicide, is used globally (825 million kg/year) in 750+ formulations. The International Agency for Research on Cancer classified glyphosate is a probable human carcinogen (Group 2A), but epidemiological studies have been lacking for its association with liver cancer and chronic liver disease. We analyzed urine specimens from 591 patients with newly diagnosed liver cancer, chronic liver disease (CLD), and healthy individuals from five different medical centers between 2011 to 2016 in Thailand.
View Article and Find Full Text PDFThailand is among countries with the highest global incidence and mortality rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). While viral hepatitis and liver fluke infections have been associated with HCC and iCCA, respectively, other environmental risk factors, overall risk factor commonality and combinatorial roles, and effects on survival have not been systematically examined. We conducted a TIGER-LC consortium-based population study covering all high-incidence areas of both malignancies across Thailand: 837 HCC, 1474 iCCA, and 1112 controls (2011-2019) were comprehensively queried on lifelong environmental exposures, lifestyle, and medical history.
View Article and Find Full Text PDFArticle Synopsis
- Hepatocellular carcinoma (HCC) is a complex cancer with diverse genetic mutations, making it challenging to study tumor cell evolution due to many inconsequential mutations.
- A new strategy was developed to analyze tumor clonality in 524 HCC patients, revealing two main evolution types: linear and non-linear, with further distinctions within non-linear evolution.
- The study found that linear HCC tumors are less aggressive and linked to specific mutations, like GTF2IRD2B, while non-linear tumors often harbor TP53 mutations, indicating distinct immune responses between the two evolution types that warrant further investigation.
Background: Cholangiocarcinoma (CCA) caused by Opisthorchis viverrini is a well-known and significant public health issue in northeastern Thailand; however, a link between pesticide exposure (PE) and CCA risk has not yet been established. Therefore, our research objective was to investigate the relationship between PE and CCA risk.
Methods: A hospital-based matched case-control study was carried out.