Publications by authors named "V Bharath Shetty"
Association of Epstein-Barr Virus and its clinical relevance in Human Papillomavirus-negative oral squamous cell carcinoma: A cohort study from South India.
Arch Oral Biol
January 2025
Objective: The study assessed the prevalence and clinical implications of Epstein Barr Virus (EBV)-positive but Human Papillomavirus (HPV)-negative oral squamous cell carcinoma (OSCC) in a tertiary care hospital setting. The overall goal was to elucidate the potential impact of EBV on OSCC disease progression and prognosis.
Design: A total of 134 surgically resected and histopathologically confirmed OSCC tumor biopsies were collected from a tertiary care hospital.
Article Synopsis
- The study investigates lymph node stromal cell cultures (LNSCs) from oral squamous cell carcinoma (OSCC) patients to understand tumor interactions for better treatment options.
- Primary cultures were developed from both metastatic and non-metastatic patient nodes, confirming their purity and revealing a variety of cell types.
- Transcriptomic and cytokine profiling showed different molecular alterations based on node status, with key insights into immune response and potential pathways for metastasis, highlighting the relevance of these models for future cancer research.
To examine the effect of using Virtual Reality distraction on salivary cortisol levels in children with Autism Spectrum Disorders (ASD) during routine dental treatments. A randomized cross-over study was designed and children with a known diagnosis of ASD, between 8 and 15 years of age, requiring routine, non-invasive dental treatments, were recruited. They were divided into 2 groups (group 1 and group 2) and scheduled for dental treatments using conventional behavior management and/or VR distraction techniques in their first and second dental visit, accordingly.
View Article and Find Full Text PDFBackground: Patient portal secure messaging allows patients to describe health-related behaviors in ways that may not be sufficiently captured in standard electronic health record (EHR) documentation, but little is known about how cannabis is discussed on this platform.
Objective: This study aimed to identify patient and provider secure messages that discussed cannabis and contextualize these discussions over periods before and after its legalization for medical purposes in Pennsylvania.
Methods: We examined 382,982 secure messages sent by 15,340 patients and 6101 providers from an integrated health delivery system in Pennsylvania, United States, from January 2012 to June 2022.
Background: Stroke is a leading cause of global morbidity and mortality, and understanding modifiable predictors of stroke outcomes is crucial. This study explores the relationship between renal function, assessed via estimated glomerular filtration rate (eGFR) and serum creatinine, and stroke mortality and functional outcomes in a cohort of acute stroke patients in India.
Methods: A prospective observational study was conducted from February 2021 to October 2022, including 104 acute stroke patients from MS Ramaiah Medical College and Hospital, Bengaluru, India.