Publications by authors named "V Beatrici"
Background: Suitable selection criteria for focal therapy (FT) are crucial to achieve success in localized prostate cancer (PCa).
Objective: To develop a multivariable model that better delineates eligibility for FT and reduces undertreatment by predicting unfavorable disease at radical prostatectomy (RP).
Design, Setting, And Participants: Data were retrospectively collected from a prospective European multicenter cohort of 767 patients who underwent magnetic resonance imaging (MRI)-targeted and systematic biopsies followed by RP in eight referral centers between 2016 and 2021.
Article Synopsis
- Multiparametric MRI and MRI-targeted biopsy are key in diagnosing prostate cancer and have been used to create new risk classification systems for predicting early biochemical recurrence after radical prostatectomy.
- A study analyzed data from 1,371 patients to compare various risk classification systems, including EAU, NCCN, CAPRA, STAR-CAP, Ploussard, and Mazzone models, using methods like Kaplan-Meier analysis and Harrell's c-index.
- The STAR-CAP classification showed the best discrimination for predicting events, with a c-index of 66%, while other systems like EAU and NCCN performed significantly worse, highlighting the importance of choosing the right classification for better patient outcomes.
Purpose: To assess the most efficient biopsy method to improve International Society of Urological Pathology (ISUP) grade group accuracy with final pathology of the radical prostatectomy (RP) specimen in the era of magnetic resonance imaging (MRI)-driven pathway.
Methods: A total of 753 patients diagnosed by transrectal MRI-targeted and systematic biopsies (namely "standard method"), treated by RP, between 2016 and 2021 were evaluated. Biopsy methods included MRI-targeted biopsy, side-specific systematic biopsies relative to index MRI lesion and combination of both.
Background: Male circumcision is a well-known old surgery, and several recently developed techniques have been scaled up, including the introduction of laser technology, as alternative approaches to overcome morbidity of conventional surgery scalpel/suture method OBJECTIVES: We aimed to perform a systematic review and meta-analysis of studies comparing laser circumcision versus conventional circumcision technique in terms of perioperative outcomes and efficacy (complications, unacceptable appearance, reoperation rate) both in children and adults.
Materials And Methods: This review was performed following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework. Continuous variables were analyzed using the inverse variance of the mean difference with a random effect, 95% confidence interval (CI), and p-value.
Article Synopsis
- Study tested prediction models for assessing prostate cancer patients' eligibility for active surveillance based on risk of adverse pathology after radical prostatectomy.
- Existing models showed poor performance in discrimination and calibration, with only slight improvements from a novel model, indicating limited effectiveness in accurately predicting patient risk.
- Results suggest that current methods, including MRI and targeted biopsies, do not reliably identify low-risk candidates for active surveillance, leading to potential misclassification issues.