Assessing Credibility in Bayesian Networks Structure Learning.

Learning Bayesian networks from data aims to create a Directed Acyclic Graph that encodes significant statistical relationships between variables and their joint probability distributions. However, when using real-world data with limited knowledge of the original dynamical system, it is challenging to determine if the learned DAG accurately reflects the underlying relationships, especially when the data come from multiple independent sources. This paper describes a methodology capable of assessing the credible interval for the existence and direction of each edge within Bayesian networks learned from data, without previous knowledge of the underlying dynamical system.

The P(III)-Amidite Based Synthesis of Stable Isotope Labeled mRNA-Cap-Structures Enables their Sensitive Quantitation from Brain Tissue.

The 5' cap structure is crucial to mRNA function, with its diverse methylation patterns depending on the cellular state. Sensitive analytical methods are sought after to quantify this cap variety also referred to as cap epitranscriptome. To address a bottleneck for accurate and precise quantitation, we report a facile and fast access to high-quality synthetic standards via a new route, involving P(III)-amidite chemistry.

Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in .

Toxin-antitoxin modules are present in many bacterial pathogens. The VapBC family is particularly abundant in members of the complex, with 50 modules present in the genome. In type IIA modules, the VapB antitoxin protein binds to and inhibits the activity of the co-expressed cognate VapC toxin protein.

Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in .

Toxin-antitoxin modules are present in many bacterial pathogens. The VapBC family is particularly abundant in members of the complex, with 50 modules present in the genome. In type IIA modules the VapB antitoxin protein binds to and inhibits the activity of the co-expressed cognate VapC toxin protein.

Simultaneous anterograde screw arthrodesis of distal interphalangeal joint and silastic proximal interphalangeal joint replacement for osteoarthritis.

We treated six patients with the combination of anterograde distal interphalangeal joint arthrodesis and Swanson prothesis proximal interphalangeal joint arthroplasty on the same finger. The results showed both bony union and flexibility, without cases of nail deformity, wound complications, tip hypersensitivity or malalignment.