Publications by authors named "V Barbier-Chassefiere"
Article Synopsis
- The causes of Parkinson's disease (PD) are not fully understood, but mitochondrial dysfunction and the accumulation of α-synuclein in Lewy bodies are significant factors.
- The study highlights the role of glycosaminoglycans (GAGs) in regulating Cathepsin D (cathD), a key enzyme in breaking down α-synuclein, indicating that GAGs may influence Parkinson's pathology.
- Results showed that manipulating GAG levels in a PD model affected cathD activity and α-synuclein levels, suggesting that GAGs could be potential targets for future research in PD treatment and neurobiology.
Skin wound healing is a natural and intricate process that takes place after injury, involving different sequential phases such as hemostasis, inflammatory phase, proliferative phase, and remodeling that are associated with complex biochemical events. The interruption or failure of wound healing leads to chronic nonhealing wounds or fibrosis-associated diseases constituting a major health problem where, unfortunately, medicines are not very effective. The objective of this study was to evaluate the capacity of Cicaderma ointment (Boiron, Lyon, France) to accelerate ulcer closure without fibrosis and investigate wound healing dynamic processes.
View Article and Find Full Text PDFGlycosaminoglycans (GAGs) are essential components of the extracellular matrix, the natural environment from which cell behavior is regulated by a number or tissue homeostasis guarantors including growth factors. Because most heparin-binding growth factor activities are regulated by GAGs, structural and functional alterations of these polysaccharides may consequently affect the integrity of tissues during critical physiological and pathological processes. Here, we investigated whether the aging process can induce changes in the myocardial GAG composition in rats and whether these changes can affect the activities of particular heparin-binding growth factors known to sustain cardiac tissue integrity.
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- Biologically active oligosaccharides related to glycosaminoglycans, particularly heparan mimetics (HMs), are gaining attention for their therapeutic potential and ability to mimic glycosaminoglycans in interacting with proteins.
- HMs can stimulate tissue repair in animal models, and researchers are using chemical methods to create a library of oligosaccharides from HMs to study their biological activities.
- The oligosaccharide H-dp12 shows promising results, regenerating tissue effectively while having low anticoagulant activity, indicating new therapeutic possibilities.
Lysosomal cathepsins have recently been reported to play crucial roles in the regulation of the mitochondrial death cascade by an unclear mechanism leading to mitochondrial membrane permeabilization. Glycosaminoglycans (GAG) are a family of ionic polysaccharides present at the lysosomal compartment and shown to inhibit lysosomal cathepsin activities. The implication of this family of polysaccharides in the regulation of the pre-mitochondrial death cascade has still not been considered.
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