Publications by authors named "V Baldin"
Article Synopsis
- Tuberculous meningitis (TBM) is a severe form of tuberculosis, and a review of studies was conducted to understand its impact on adults in high TB incidence countries.
- Out of 11,855 articles searched, 21 were reviewed, and 15 included in the meta-analysis, revealing a 25% overall mortality rate and a staggering 70% death rate in Africa.
- The study found inconsistencies in diagnostic methods and treatment approaches, indicating a pressing need for standardized guidelines to improve diagnosis and treatment to lower mortality rates, especially in African regions.
An arylsulfonamide that targets cell wall biosynthesis in .
Antimicrob Agents Chemother
November 2024
Article Synopsis
- - We synthesized a new arylsulfonamide that showed effectiveness against both extracellular and intracellular bacilli, while also displaying selectivity in its action against HepG2 cells.
- - The drug disrupts bacterial cell wall synthesis, likely targeting the MmpL3 protein, which is known to export mycolic acids necessary for the bacterial cell wall.
- - A specific mutation in the MmpL3 protein led to some resistance against the drug, further supporting the idea that MmpL3 is the main target of the compound's action.
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis complex, still presents significant numbers of incidence and mortality, in addition to several cases of drug resistance. Resistance, especially to isoniazid, which is one of the main drugs used in the treatment, has increased. In this context, N-acylhydrazones derived from isoniazid have shown important anti-Mycobacterium tuberculosis activity.
View Article and Find Full Text PDFAntibiotic resistance is one of the biggest threats to global health, and this study aimed better understand how the efflux pumps are related to this process in tuberculosis clinical isolates. The combination of antibiotics plus efflux pumps (EP) inhibitors was able to restore the susceptibility of clinical isolates in 100% of aminoglycosides resistance and 33.3% of the fluoroquinolones resistance.
View Article and Find Full Text PDFThe development of drugs is essential to eradicate tuberculosis. Sixteen 3,5-dinitrobenzoylhydrazone () derivatives and their synthetic precursors 3,5-dinitrobenzoylhydrazide () and methyl ester () were screened for their anti- () potential. Twelve compounds had minimum inhibitory concentration (MIC) ranging from 0.
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