Antiviral and Immunomodulatory Effects of Zafirlukast Against Flaviviruses via Inhibition of the TNF Signaling Pathway.

The two most clinically important members of the flavivirus genus, Zika virus (ZIKV) and dengue virus (DENV) pose a significant public health challenge. They cause a range of diseases in humans, from hemorrhagic to neurological manifestations, leading to economic and social burden worldwide. Nevertheless, there are no approved antiviral drugs to treat these infections.

Emerging Therapeutics in the Fight Against EV-D68: A Review of Current Strategies.

Enterovirus-D68 (EV-D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV-D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV-D68 positive.

Infectomics of Chikungunya Virus: Roles Played by Host Factors.

Chikungunya virus (CHIKV), prevalent in tropical regions, is known for causing frequent outbreaks, particularly in Central Africa, South America, and Southeast Asia. It is an arbovirus transmitted by the Aedes (Ae.) aegypti and Ae.

Ternion Approach of Surgical Coverage in Single Tooth Recession: A Case Report on a Novel Technique.

The goal of mucogingival surgery or periodontal plastic surgery is to preserve gingiva, remove aberrant frenum or muscle attachments, increase vestibular depth, and correct the denuded root surface. Recession coverage is indeed a challenging technique, whereas covering the exposed roots is not only important for aesthetic reasons but also for preventing further issues such as tooth sensitivity, root decay, and loss of supporting bone. A coronally advanced flap (CAF) is one of the most common procedures done for recession coverage because of the concept that the coronal advancement of a flap without tension to cover the exposed root surface or CAF with autogenous grafts results in bulk and improves the thickness of the gingival tissue, increasing the stability and aesthetics of the result.