[Adenosine A2A receptor as a drug target for treatment of sepsis].

Sepsis is a generalized infection accompanied by response of the body that manifests in a clinical and laboratory syndrome, namely, in the systemic inflammatory response syndrome (SIRS) from the organism to the infection. Although sepsis is a widespread and life-threatening disease, the assortment of drugs for its treatment is mostly limited by antibiotics. Therefore, the search for new cellular targets for drug therapy of sepsis is an urgent task of modern medicine and pharmacology.

[The double ratio as an index of the normal functional organization of the human heart cycle at rest].

The three-phase temporal dynamic structure of the cardiac cycle of man was assayed with the ECG curves using the double ratio. The magnitude of the double ratio is virtually permanent for normal men at rest, being independent of the sex or age. The double ratio within the limits 1.