[The determination of beta-casein gene expression and the assessment of hormonal homeostasis in gynecomastia patients and in breast cancer in men].

beta-Casein genes expression in breast epithelium was studied in male patients with various forms of gynecomastia and cancer. Blood serum levels of pituitary, sex and glucocorticoid hormones were assayed in 29 patients with gynecomastia and 22 cases of breast cancer, and in 25 of them beta-casein genes expression was evaluated additionally. Activation of the above genes was established in the tissues studied.

[The function of the hypophysis, adrenal cortex and gonads in men with breast cancer].

It was established that male patients with breast cancer showed significant disorders of the functional state of the pituitary, adrenal cortex and gonads. This may be significant for the efficacy of combined treatment.

[Functional state of the hypophysis, adrenal cortex and gonads in patients with gynecomastia].

Patients with gynecomastia revealed simultaneous increase in blood levels of estrogens, glucocorticoids and pituitary (first of all, gonadotropic) hormones associated with a decrease in blood-androgen concentration. Such combination of disturbances may account for hyperplasia of the male breast.