Publications by authors named "V B Ryvkin"
Article Synopsis
- PKD is a family of three kinases (PKD-1, -2, and -3) that regulate key biological processes like cell growth, migration, and survival; PKD1 is especially crucial for wound healing and tumor development in mice.
- Unlike in mice, PKD1 is absent in human skin cells (keratinocytes), leading to differences in how PKD isoforms function in humans, particularly regarding cell growth responses.
- The study shows that PKD2 promotes growth in human keratinocytes, while PKD3 is essential for cell proliferation; loss of PKD3 leads to severe proliferation issues and an inability to properly regenerate tissue, highlighting the complexity of PKD signaling in skin health.
Context: Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS.
Objective: We tested whether polycystic ovary syndrome (PCOS) is associated with increased ATM infiltration, especially of inflammatory subtype identified by the CD11c marker.
Design And Setting: We conducted a case-control study at an academic medical center in the United States.
The paper considers information about cancer incidence (solid tumors) among liquidators of the Chernobyl accident, which occurred in April 1986. The information was accumulated in the Russian National Medical and Dosimetric Registry (RNMDR) in the period from 1986 to early 1996. The RNMDR contains individual dosimetric and annual check-up data on liquidators resident in Russia.
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