Characterizing Parkinson's Disease-Associated Pain in Native Patients with Malayalam Version of the King's Parkinson's Disease Pain Scale.

Background And Objectives: Pain is an important non-motor symptom in Parkinson's disease (PD) and is often under-recognized. Pain is also a symptom frequently reported by non-PD elderly subjects. The King's Parkinson's Disease Pain Scale (KPPS) is a valid tool to characterize and quantify pain in PD and has been translated into several languages.

Design, synthesis, , and studies of novel isatin-hybrid hydrazones as potential triple-negative breast cancer agents.

Recent advances in cancer therapy have been made possible by monoclonal antibodies, domain antibodies, antibody drug conjugates, The most impact has come from controlling cell cycle checkpoints through checkpoint inhibitors. This manuscript explores the potential of a series of novel -benzyl isatin based hydrazones (5-25), which were synthesized and evaluated as anti-breast cancer agents. The synthesized hydrazones of -benzyl isatin were screened against two cell lines, the MDA-MB-231 breast cancer cell line and the MCF-10A breast epithelial cell line.

Assessment of Barriers and Enablers for Implementing a Population-Based Childhood Cancer Registry in Chennai, India.

Background: Despite most childhood cancer cases being diagnosed in low- and middle-income countries, there is a significant deficit of population-based childhood cancer registries (PBCCRs) in these regions. To address this critical gap, we established India's first dedicated PBCCR in Chennai on October 4, 2022, covering children aged 0-19. This study aims to identify the barriers and enablers to implementing the Chennai PBCCR.

Sign, Signifier and Signified in Schrödinger's box.

This study of the article proposes an interdisciplinary approach, integrating quantum mechanics and structuralism to elucidate the complex dynamics of signification. By paralleling the ambiguous nature of subatomic particles with the linguistic system, the study examines the arbitrary relationship between sign, signifier, and signified through quantum principles. Key concepts from quantum mechanics, such as wave-particle duality, superposition, entanglement, and observer effect, are applied to Saussure's theory of signs, revealing intriguing analogies between the two domains.

Effects of buffers on spray-freeze-dried/lyophilized high concentration protein formulations.

Solid-state protein formulations are known to exhibit enhanced storage stability compared to their liquid dosage form counterparts. pH is one of the factors affecting the stability of protein formulations. The pH of protein formulations in the solution could be influenced by the buffer used, directly impacting their solid-state stability.