Publications by authors named "V B Polishchuk"
Article Synopsis
- Ceroid lipofuscinosis neuronal (CLN) is a rare neurodegenerative disorder that affects children, causing issues like epilepsy, vision loss, and early death.
- A study analyzed 8 patients with different types of CLN who underwent umbilical cord blood transplant (UCBT) between 2012 and 2020, finding that all patients had successful donor cell engraftment without severe transplant-related deaths.
- Complications like severe graft-versus-host disease and infections were noted, but overall, UCBT showed promise in stabilizing some patients' conditions, highlighting the need for more research and longer follow-up to fully understand its impact.
Article Synopsis
- Mucosal immunity, particularly through secretory immunoglobulin A (sIgA), is crucial for preventing and influencing COVID-19 outcomes.
- A study involving 69 moderate COVID-19 patients compared the effects of a bacteria-based immunostimulant, Immunovac VP4, with standard therapy on sIgA levels and disease progression.
- Results showed that using Immunovac VP4 led to higher sIgA production, reduced C-reactive protein (CRP) levels, shorter fever duration, and decreased hospitalization compared to the control group.
Polymethine dyes of tetraanionic nature comprising 1,3,2-dioxaborine rings in the polymethine chain and end-groups of different electron-accepting abilities have been synthesized. They can be considered as oligomeric polymethines, where a linear conjugated π-system passes through three 1,3,2-dioxaborine units and a number of tri- and dimethine π-bridges between two end-groups. The obtained dyes exhibit near-infrared absorption and fluorescence, with molar absorption coefficients reaching as high as 564000 M cm in DMF, rendering them among the strongest absorbers known.
View Article and Find Full Text PDFWhile therapies targeting CD19 by antibodies, chimeric antigen receptor T cells (CAR-T), and T cell engagers have improved the response rates in B cell malignancies, the emergence of resistant cell populations with low CD19 expression can lead to relapsed disease. We developed an in vitro model of adaptive resistance facilitated by chronic exposure of leukemia cells to a CD19 immunotoxin. Single-cell RNA-Seq (scRNA-Seq) showed an increase in transcriptionally distinct CD19lo populations among resistant cells.
View Article and Find Full Text PDFThe Lviv Military Medical Centre is the main hospital responsible for the management of wounded military personnel in Western Ukraine. Since the full-scale invasion of our country in 2022, we have had to rapidly adapt our department to managing a large influx of complex facial battle injuries. These wounds are generally from large explosive fragments such as from shells and commonly produce avulsive defects of the facial bones and overlying soft tissues.
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