[Corneal extracellular matrix].

The paper analyzes the structural and functional state of the corneal extracellular matrix (ECM). It presents the currently available data on the role of connective tissue in health and during corneal pathological processes. Numerous morphological studies have provided evidence that the extracellular contact mechanisms characterized by extracellular and matrix-cell interactions are fundamental processes of corneal immunobiology.

[Morphological features of regenerative-reparative processes in the cornea exposed to synthetic analogues of endogenous peptide fragments of protein S100b in an experiment].

The effects of two 5-membered (SP5, SP6) endogenous synthetic peptide fragments of protein S100b on the course of regenerative-reparative processes in the corneas of Wistar rats were morphologically studied after making a graduated injury. Conjunctival or endonasal injection of the peptides was made at two concentrations of 10(-6) and 10(-8) M. The study peptides were found to have a modulating effect on regenerative-reparative processes regardless of the route of administration and to induce accelerated and qualitative corneal wound healing as compared with the controls.

[A surgical treatment for neovascular terminal glaucoma (preliminary communication)].

In 40 patients with terminal neovascular glaucoma of various genesis (visual acuity 0 to wrong light projection), 4 rectus muscles were tightly ligated at the insertion site of their strings to the sclera of the eyeball with silk threads under local anesthesia. The threads were not postoperatively removed and left under the conjunctiva (Invention Patent No. 2286752 of November 10, 2006).

[Use of S100b protein for optimization of cornea regeneration after surgery].

The results presented suggest a modulating effect of protein S100b on the course of inflammation in the cornea. In the presence of this protein, secretion of proteoglycans and collagen increases, their interrelationship is restored and tissue specificity of extracellular matrix is ensured, which allows preservation of the cornea transparency. Protein S100b appears to be a promising drug for ophthalmology, especially after refractional surgery on the cornea.