Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals.

Background: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 °C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed.

Methods: Experiments were conducted using nerve terminals isolated from rat cortex (synaptosomes).

Environmental problems associated with decommissioning the Chernobyl Nuclear Power Plant Cooling Pond.

Decommissioning of nuclear power plants and other nuclear fuel cycle facilities associated with residual radioactive contamination of their territories is an imperative issue. Significant problems may result from decommissioning of cooling ponds with residual radioactive contamination. The Chernobyl Nuclear Power Plant (ChNPP) Cooling Pond is one of the largest self-contained water reservoirs in the Chernobyl region and Ukrainian and Belorussian Polesye region.

[Using marker of the mitochondrial pore opening in diagnostics of patients with myocardial ischemic lesions].

In the article a possibility of definition of level of the mitochondrial factor (MF) for early diagnostics of the myocardial ischemic damages at patients during heart surgery was investigated. The reperfusion damages of heart were manifested by MPTP activation and MF release. The rising of MF level during a cardioplegia is comparable to level, which has been noted at patients with angina before operation of aorto-coronary shunting.

[Early marker of myocardial injury of the ischemia-reperfused heart in dogs and during operations with artificial circulation in humans].

The model of ischemia/reperfusion was reproduced on 9 unconscious dogs. Simultaneously with registration of indexes heart work, hemodynamic and mitochondrial factor (MF) in venous blood from right atrium was defined. Measures were done by spectrophotometria.

[The heart pumping function and the systemic regulation of blood circulation in groups of heart surgery patients].

General properties of cardiovascular system functioning in the groups of postoperative patients in the cardiac surgery clinic were studied using the information technology (IT), combined the methods of cluster and nonlinear regression analysis and computer simulation. It was shown, that in all five separated groups of observations (clusters) the direct dependency of cardiac (CI) and stroke (SI) indexes on central venous pressure (CVP) was determined by the variations of total peripheral resistance and reactions of venous tone (u), contractility (E) and heart rate (HR), oriented on the stabilisation of mean aortic pressure (AP) on approximately the same level. Significant differences between the characteristics CI(CVP), SI(CVP) in the groups were determined by the level of E (especially of the right ventricle) and diastolic tone of the heart.