Publications by authors named "V B Hunt"
Article Synopsis
- * The study faced challenges like clinics dropping out and care disruptions due to COVID-19, along with significant differences in patient populations between the program and usual care, leading to the use of propensity score matching to adjust for these discrepancies.
- * Key lessons learned emphasized the importance of adapting methods in response to unexpected issues and weighing the tradeoffs of pragmatic design elements in research to generate useful evidence for clinical practice.
A neuropathological hallmark of Parkinson's disease (PD) is the aggregation and spreading of misfolded α-synuclein (αSyn) protein. In this study, a selection method was developed to identify aptamers that showed affinity for monomeric αSyn and inhibition of αSyn aggregation. Aptamer exhibited strong inhibition of αSyn aggregation by transmission electron microscopy and Thioflavin T fluorescence.
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- The genus of parasitic nematodes is significant both for its complex life cycle and its role as a health threat to humans, categorized as a neglected tropical disease by the WHO.
- A group of researchers has outlined thirteen key questions focused on the biology and infection mechanics of these nematodes, aiming to guide future studies.
- This article contributes to the Theo Murphy meeting issue titled "omics to worm-free populations," indicating a broader discussion on scientific approaches to managing these parasites.
Syntenic relationship of chromosomes in species and based on the chromosome-level genome assemblies.
Philos Trans R Soc Lond B Biol Sci
January 2024
The clade, to which the parasitic nematode genus belongs, contains taxa with diverse lifestyles, ranging from free-living to obligate vertebrate parasites. Reproductive strategies are also diverse in this group of nematodes, employing not only sexual reproduction but also parthenogenesis, making it an attractive group to study genome adaptation to specific conditions. An in-depth understanding of genome evolution, however, has been hampered by fragmented genome assemblies.
View Article and Find Full Text PDFAmong nematodes, the free-living model organism boasts the most advanced portfolio of high-quality omics data. The resources available for parasitic nematodes, including spp., however, are lagging behind.
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