[DYNAMICS OF METABOLIC CHARACTERISTICS, MARKERS OF OXIDATIVE STRESS AND VASCULAR WALL DAMAGE DURING TREATMENT OF OBESE PRE-DIABETIC PATIENTS].

We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive dynamics of the above metabolic parameters with normalization of carbohydrate metabolism in 60% of the patients and angioprotective effect of prescribed therapy. The proposed treatment can be used to prevent diabetes mellitus.

[Changes of homeostasis and immunity in the acute period of ischemic stroke].

We studied homeostasis, immunity and rheological blood properties in the acute period of ischemic stroke. As intravascular blood coagulation and depression of fibrinolysis happen the amount of "rough" red blood cells increased as well as their aggregates enlarged in size. These changes haven't been seen in patients with lacunar stroke and transient ischemic attacks.