Publications by authors named "V B Grigoriev"
Article Synopsis
- Metastatic progression in cancers worsens survival rates and complicates treatment, prompting the development of an mRNA therapy aimed at inhibiting metastasis by targeting activin A, a key factor in metastasis and cachexia.
- This therapy uses follistatin mRNA lipid nanoparticles to effectively reduce activin A levels, resulting in lowered tumor burden and less metastatic spread in a mouse model of head and neck cancer.
- Treated mice showed less metastatic occurrence, preserved muscle and fat tissue, and a good safety profile, suggesting the therapy could be widely applicable across different cancers due to the common overexpression of activin A.
Article Synopsis
- The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
- It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
- The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.
mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for treating various diseases. While mRNA vaccines anticipate immunogenicity, the associated reactogenicity of mRNA-loaded LNPs poses significant challenges, especially in protein replacement therapies requiring multiple administrations, leading to adverse effects and suboptimal therapeutic outcomes. Historically, research has primarily focused on the reactogenicity of mRNA cargo, leaving the role of LNPs understudied in this context.
View Article and Find Full Text PDFThe ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high p_{T}) hadron trigger in proton-proton and central Pb-Pb collisions at sqrt[s_{NN}]=5.02 TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions.
View Article and Find Full Text PDFThe aim of this study was to evaluate a new B-1895 probiotic as a feed additive for farmed trout. Final weight, absolute and average daily gain of fish, and average daily growth rate were higher in the group that received the probiotic than in the control group (p<0.05).
View Article and Find Full Text PDF