Publications by authors named "V B Braun"
TonB is an essential component of an energy-generating system that powers active transport across the outer membrane (OM) of compounds that are too large or too scarce to diffuse through porins. The TonB-dependent OM transport proteins (TBDTs) consist of β barrels forming pores that are closed by plugs. The binding of TonB to TBDTs elicits plug movement, which opens the pores and enables nutrient translocation from the cell surface into the periplasm.
View Article and Find Full Text PDFCentrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be engaged by the "mitotic surveillance" or the "PIDDosome pathway", respectively.
View Article and Find Full Text PDFArticle Synopsis
- Tetrapyrroles like heme, chlorophyll, and vitamin B are crucial for metabolic processes and are derived from 5-aminolevulinic acid (5-ALA), which can be synthesized via a single enzyme or a two-enzyme pathway.
- Researchers analyzed metagenomic datasets to find alaS homologs (valaS) in marine and freshwater phages, indicating these viruses may have genes for tetrapyrrole biosynthesis.
- The study demonstrates that a freshwater phage valaS can functionally complement a 5-ALA deficient E. coli strain, confirming its role as an auxiliary metabolic gene and highlighting the significance of tetrapyrrole metabolism in phage biology.
Article Synopsis
- Acupuncture is increasingly being considered for use in surgical and postoperative care, but the current research is inconsistent and often of low quality, especially regarding its application after intestinal surgeries.
- A systematic review of 700 records identified 8 trials demonstrating that acupuncture can help reduce pain, lower analgesic use, alleviate nausea, and improve gastrointestinal recovery post-abdominal surgery, although many studies had methodological issues leading to high risk of bias.
- To establish clear evidence for acupuncture's effectiveness, future studies need to adopt standardized protocols, precise interventions, and reliable methods for measuring outcomes.
[Mycotoxin intoxication in 54 dogs after ingestion of walnuts].
Tierarztl Prax Ausg K Kleintiere Heimtiere
August 2024
Objective: The aim of this retrospective study was to decribe the intoxication with tremorgenic mycotoxins subsequent to the ingestion of walnuts in a large population of dogs and the evaluation of the development of the clinical signs under the initiated treatment.
Material And Methods: The study included 54 dogs exhibiting signs of tremor, hyperesthesia, hyperthermia and ataxia, in particular a few hours following observed ingestion of walnuts or its justified suspicion.
Results: The patients were presented to the clinic mostly during winter and spring.