Analyzing the dynamics of COVID-19 transmission in select regions of the Philippines: A modeling approach to assess the impact of various tiers of community quarantines.

The COVID-19 pandemic has significantly impacted communities worldwide, and effective management strategies are critical to reduce transmission rates and minimize the impact of the disease. In this study, we modeled and analyzed the COVID-19 transmission dynamics and derived relevant epidemiological values for three regions of the Philippines, namely, the National Capital Region (NCR), Davao City, and Baguio City, under different community quarantine implementations. The unique features and differences of these regions-of-interest were accounted for in simulating the disease spread and in estimating key epidemiological parameters fitted to the reported COVID-19 cases.

Investigation of the agricultural reuse potential of urban wastewater and other resources derived by using membrane bioreactor technology within the circular economy framework.

The European Union, as delineated in Regulation (EU) 2020/741, sets forth minimum criteria for the reuse of wastewater. Directive 86/278/CEE sets the regulations for the reuse of sewage sludge in agriculture. This study aimed to investigate the treated water derived from a pilot plant situated in Granada, Spain, that utilizes membrane bioreactor technology to process real urban wastewater with the quality standards necessary for agricultural reuse.

Betaglycan sustains HGF/Met signaling in lung cancer and endothelial cells promoting cell migration and tumor growth.

Persistent HGF/Met signaling drives tumor growth and dissemination. Proteoglycans within the tumor microenvironment might control HGF availability and signaling by affecting its accessibility to Met (HGF receptor), likely defining whether acute or sustained HGF/Met signaling cues take place. Given that betaglycan (BG, also known as type III TGFβ receptor or TGFBR3), a multi-faceted proteoglycan TGFβ co-receptor, can be found within the tumor microenvironment, we addressed its hypothetical role in oncogenic HGF signaling.

National Outpatient Sexually Transmitted Infection Testing in Pregnant Patients in the United States.

Sexually transmitted infections (STIs) continue to increase in the United States and pregnant patients who acquire STIs are at risk for serious complications. This study estimated the utilization of preventative STI testing among pregnant outpatients on a national scale. This was a retrospective, cross-sectional study of outpatient visits in the National Ambulatory Medical Care Survey from 2014 to 2016 and 2018 to 2019.

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron types.

The extraordinary diversity of neuron types in the mammalian brain is delineated at the highest resolution by subtle gene expression differences that may require specialized molecular mechanisms to be maintained. Neurons uniquely express the longest genes in the genome and utilize neuron-enriched non-CG DNA methylation (mCA) together with the Rett syndrome protein, MeCP2, to control gene expression, but the function of these unique gene structures and machinery in regulating finely resolved neuron type-specific gene programs has not been explored. Here, we employ epigenomic and spatial transcriptomic analyses to discover a major role for mCA and MeCP2 in maintaining neuron type-specific gene programs at the finest scale of cellular resolution.