Artificial Intelligence and Machine Learning in Ocular Oncology, Retinoblastoma (ArMOR): Experience with a Multiracial Cohort.

The color variation in fundus images from differences in melanin concentrations across races can affect the accuracy of artificial intelligence and machine learning (AI/ML) models. Hence, we studied the performance of our AI model (with proven efficacy in an Asian-Indian cohort) in a multiracial cohort for detecting and classifying intraocular RB (iRB). Retrospective observational study.

Trailblazer in Medicine: The Inspirational Journey of Dr. Anandibai Gopalrao Joshee.

Dr. Anandibai Joshee, emerging from a patriarchal society in Maharashtra, India, stands as a trailblazer in the annals of medical history, not only as the first Indian woman to earn a degree in Western medicine but also as a fervent advocate for women's rights. This paper delves into her life, exploring her contributions to the medical field, her advocacy for women's education, and the cultural impact she left on both India and the international community.

Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.

The loss of RAB25 expression-RAS superfamily of GTPase characteristic of numerous breast cancers-corresponds with H-RAS point mutations, particularly in triple-negative breast cancers (TNBC), a subtype associated with a poor prognosis. To address the poorly understood factors dictating the progression of TNBC tumors, we examine the cooperative effects that loss of RAB25 expression in human mammary epithelial cell (HMEC) lines with H-RAS mutations confers in tumorigenesis. HMECs were immortalized by transduction with LXSN CDK4 R24C, a mutant form of cyclin-dependent kinase, followed by transduction with hTERT, a catalytic subunit of the telomerase enzyme.

Design of Linear B Cell Epitopes and Evaluation of Their Antigenicity, Allergenicity, and Toxicity: An Immunoinformatics Approach.

Immunoinformatics is a modern branch of science formed as a result of the intersection between immunology and computer science. One of the important steps in the design of multi-epitope vaccines is the prediction of B cell epitopes. B cell epitopes are of two types, linear and discontinuous.

Evaluation of sterol‑o‑acyl transferase 1 and cholesterol ester levels in plasma, peritoneal fluid and tumor tissue of patients with endometrial cancer: A pilot study.

Endometrial cancer (EC) is the most prevalent gynecological malignancy. Abnormal accumulation of sterol-O-acyl transferase 1 (SOAT1) and SOAT1-mediated cholesterol ester (CE) contributes to cancer progression in various malignancies, including ovarian cancer. Therefore, it was hypothesized that similar molecular changes may occur in EC.