Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis.

Objective: A prototype infrared attenuated total reflection (IR-ATR) laser spectroscopic system designed for classification of human cartilage tissue according to its histological health status during arthroscopic surgery is presented. Prior to real-world applications, this so-called osteoarthritis (OA) scanner has been tested at conditions revealing the challenges associated with complex sample matrices and the accordingly obtained sparse spectral datasets.

Methods: studies on human knee cartilage samples at different contact pressures (i.

Multimodal fiber probe for simultaneous mid-infrared and Raman spectroscopy.

A fiber probe has been developed that enables simultaneous acquisition of mid-infrared (MIR) and Raman spectra in the region of 3100-2600 cm. Multimodal measurement is based on a proposed ZrO crystal design at the tip of an attenuated total reflection (ATR) probe. Mid-infrared ATR spectra are obtained through a pair of chalcogenide infrared (CIR) fibers mounted at the base of the crystal.

LED-Based Desktop Analyzer for Fat Content Determination in Milk.

In dairy, there is a growing request for laboratory analysis of the main nutrients in milk. High throughput of analysis, low cost, and portability are becoming critical factors to provide the necessary level of control in milk collection, processing, and sale. A portable desktop analyzer, including three light-emitting diodes (LEDs) in the visible light region, has been constructed and tested for the determination of fat content in homogenized and raw cow's milk.

Intraoperative assessment of resection margins by Raman spectroscopy to guide oral cancer surgery.

Patients with oral cavity cancer are almost always treated with surgery. The goal is to remove the tumor with a margin of more than 5 mm of surrounding healthy tissue. Unfortunately, this is only achieved in about 15% to 26% of cases.