Publications by authors named "V Arolt"
Background: Employment and relationship are crucial for social integration. However, individuals with major psychiatric disorders often face challenges in these domains.
Aims: We investigated employment and relationship status changes among patients across the affective and psychotic spectrum - in comparison with healthy controls, examining whether diagnostic groups or functional levels influence these transitions.
Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD.
View Article and Find Full Text PDFBackground: The Personalized Advantage Index (PAI) shows promise as a method for identifying the most effective treatment for individual patients. Previous studies have demonstrated its utility in retrospective evaluations across various settings. In this study, we explored the effect of different methodological choices in predictive modelling underlying the PAI.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores the role of epigenetic mechanisms, specifically DNA methylation, in predicting treatment response to antidepressants for patients with major depressive disorder (MDD) based on a large sample size of 230 patients.
- - Researchers used DNA methylation analysis and found suggestive evidence linking altered methylation patterns at several specific sites to how well patients responded to naturalistic antidepressant treatment and SSRIs/SNRIs.
- - The findings indicate that understanding DNA methylation may help improve personalized treatment strategies for MDD in the future, although further research is needed for validation.
Article Synopsis
- Anxiety disorders impact brain connectivity, but how this varies among different types of anxiety disorders (like panic disorder and social anxiety disorder) isn't fully understood due to limited studies.
- Researchers examined the brain connectivity of 439 anxiety disorder patients and 105 healthy controls using resting-state fMRI, finding notable differences in connectivity patterns, especially in panic disorder and agoraphobia patients.
- The study revealed that panic disorder patients had increased connectivity in brain regions linked to emotion regulation, unlike those with social anxiety disorder or specific phobia, suggesting the potential for personalized treatment approaches based on these neurological differences.