Publications by authors named "V Arocas"
Article Synopsis
- Serpin E2 (PN-1) is a glycoprotein that inhibits thrombin and contributes to the regulation of the plasminergic system.
- An ELISA was developed to accurately measure human PN-1 levels in various biological fluids, including plasma and aortic tissue.
- The study found consistent PN-1 quantification with high recovery rates in samples, making this ELISA a valuable tool for future research on the role of serpin E2 in different clinical contexts.
Article Synopsis
- The study investigates the expression of Syndecan-1 (SDC-1), a heparan sulfate proteoglycan, in relation to thoracic aortic aneurysm (TAA) pathology.
- Human TAA specimens showed a significant increase in SDC-1 mRNA (3.6-fold) and protein (2.3 times) compared to healthy tissues, mainly expressed by smooth muscle cells.
- Despite these increases, SDC-1 does not appear to influence the progression or rupture of TAA, suggesting it could serve as a potential biomarker for the disease instead.
We previously identified the inhibitory serpin protease nexin-1 (PN-1) as an important player of the angiogenic balance with anti-angiogenic activity in physiological conditions. In the present study, we aimed to determine the role of PN-1 on pathological angiogenesis and particularly in response to ischemia, in the mouse model induced by femoral artery ligation. In wild-type (WT) muscle, we observed an upregulation of PN-1 mRNA and protein after ischemia.
View Article and Find Full Text PDFThe balance between proteases and protease inhibitors plays a critical role in tissue remodeling during cardiovascular diseases. Different serine protease inhibitors termed serpins, which are expressed in the cardiovascular system, can exert a fine-tuned regulation of protease activities. Among them, protease nexin-1 (PN-1, encoded by ) is a very powerful thrombin inhibitor and can also inactivate plasminogen activators and plasmin.
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