Publications by authors named "V Aoki"
Background: Janus kinase inhibitors (JAKi) have the potential to alter the landscape of atopic dermatitis (AD) management dramatically, owing to promising efficacy results from phase III trials and their rapid onset of action. However, JAKi are not without risk, and their use is not appropriate for all patients with AD, making this a medication class that dermatologists should understand and consider when treating patients with moderate-to-severe AD.
Objectives: To provide a consensus expert opinion statement from the International Eczema Council (IEC) that provides a pragmatic approach to prescribing JAKi, including choosing appropriate patients and dosing, clinical and laboratory monitoring and advice about long-term use.
Article Synopsis
- Current treatment recommendations for atopic dermatitis (AD) may not adequately address patients' needs and goals, prompting the development of new strategies for management.
- An international team of dermatology experts created the Aiming High in Eczema/Atopic Dermatitis (AHEAD) recommendations, incorporating patient input and utilizing a modified voting process to achieve consensus on treatment targets.
- The AHEAD approach emphasizes shared decision-making with patients selecting troublesome symptoms while clinicians assess severity; it aims for minimal disease activity as a goal, achieving significant agreement among experts on the proposed guidelines.
Article Synopsis
- * Overall, TCI usage surged by 66%, with high-sociodemographic-index (SDI) countries consuming significantly more TCIs—11.2 times higher than low-middle/low-SDI countries.
- * The findings indicate a strong correlation between a country's SDI and geographic location with TCI utilization, while the burden of AD, measured in disability-adjusted life years (DALYs), showed no significant impact on drug usage levels.
The objective was to study a large, international, ethnically diverse population of patients with atopic dermatitis (AD) to support the creation of patient-centric recommendations for AD management. Qualitative data were generated from 45-min, 1:1 telephone interviews conducted across 15 countries in each patient's native language. Interviews explored the impact of AD on patients' lives, patients' most important symptoms, treatment expectations, and treatment decision-making.
View Article and Find Full Text PDFLichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are primary cicatricial alopecia that cause a major impact on quality of life due to irreversible hair loss and symptoms as itching, burning and pain. They are characterized by permanent loss of hair follicle stem cells (HFSCs) by pathomechanisms still poorly understood, resulting in poor efficacy of currently available treatments. Caveolae are flask-shaped lipid rafts invaginated within the plasma membrane of multiple cell types.
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