Publications by authors named "V Amanatidou"
Article Synopsis
- Diagnosing pediatric tuberculosis (TB) is complicated, but changes in host gene expression in blood can help identify biomarkers and improve understanding of the immune response in children with TB.* -
- The study involved stimulating blood samples from 102 children with confirmed TB, TB infection, pneumonia, and healthy controls, and analyzing the gene expression differences using microarrays.* -
- Researchers identified specific gene signatures that effectively distinguish TB from pneumonia, with high accuracy (AUC of 100% for one gene and 91.7% for a combination of two genes), paving the way for new diagnostic tests aligned with WHO standards.*
Objective: To assess interferon-gamma inducible protein 10 (IP-10) as a diagnostic marker for tuberculous infection in children, particularly in relation to its differential diagnostic performance in young children.
Design And Results: A case-control study was conducted among 161 children and adolescents (mean age 6.3 years ± standard deviation 1.
Objective: To evaluate the effect of age upon QuantiFERON-TB Gold-In-Tube (QFT-IT) assay outcome among children examined for latent tuberculosis infection (LTBI).
Study Design: A cross-sectional study was conducted among 761 children (mean age ± SD: 7.84 ± 4.
Setting: A hospital referral center for childhood tuberculosis (TB).
Objective: To evaluate the epidemiological and clinical features of childhood TB in the Greater Athens area in the last decade.
Design: We retrospectively reviewed the medical records of patients aged <14 years treated for active TB between January 2000 and December 2009 at our pediatric TB clinic and compared the results with the patient turnover during the previous decade (1990-1999).
Impact of the Gen-Probe Amplified MTD® Test on tuberculosis diagnosis in children.
Int J Tuberc Lung Dis
September 2012
Objective: To evaluate the performance of the Gen-Probe Amplified MTD® Test (AMTD) for childhood tuberculosis (TB) diagnosis compared to conventional culture.
Design: We retrospectively studied 121 childhood cases (73 males; median age 7 years, range 1-16). Pulmonary samples (104/152, 68%) included gastric aspirates (n = 53), induced sputum samples (n = 43), bronchial aspirates and bronchoalveolar lavage (n = 8).