Publications by authors named "V Allot"
Background: Kidney transplant recipients and patients receiving hemodialysis are immunocompromised populations that are prioritized for COVID-19 vaccination but were excluded from clinical trials of SARS-CoV-2 mRNA vaccines. Antibody titers and rates of seroconversion after vaccination are lower among patients with CKD and those taking immunosuppressants compared with controls. Data are lacking regarding their humoral response to vaccination to prevent COVID-19.
View Article and Find Full Text PDFIntroduction: Clinical decision-making about care plans can be difficult for very elderly people with advanced chronic kidney disease (CKD). Current guidelines propose the use of prognostic tools predicting end stage renal disease (ESRD) to assist in a patient-centered shared decision-making approach. Our objective was to evaluate the existing risk model scores predicting ESRD, from data collected for a French prospective multicenter cohort of mainly octogenarians with advanced CKD.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a population pharmacokinetics model for gentamicin specifically for patients undergoing dialysis, focusing on optimal dosing using Monte Carlo simulations to analyze different MIC breakpoints.
- It involved 23 patients and 141 gentamicin samples, considering factors like weight and dialysis characteristics to develop a fitting model that predicts drug concentration outcomes.
- Findings suggest that standard gentamicin doses are inadequate for dialysis patients and recommend higher doses (3-8 mg/kg/day) given just before dialysis to effectively treat infections related to specific MIC levels.
Article Synopsis
- A working group formed in 2015 aimed to gather data on patients with CKD stage 5 to enhance understanding of their access to renal replacement therapy (RRT) and future healthcare needs.
- During a study from September 2017 to March 2018, 390 patients were included across 21 centers, with median age 71.4 years and a significant portion being diabetic; most patients had RRT projects in place.
- The pilot study highlighted the feasibility of this data collection, which can inform public health initiatives and improve local nephrology practices, but also emphasized the need for dedicated resources to fully track patient care.
Treatment plans and outcomes in elderly patients reaching advanced chronic kidney disease.
Nephrol Dial Transplant
December 2018
Background: Elderly patients with advanced chronic kidney disease require accurate outcome descriptions to make treatment decisions.
Methods: The PSPA [Parcours de soins des personnes âgées (Treatment pathways for elderly patients)] prospective multicentre cohort study included 573 such patients with a median age of 82 [interquartile range (IQR) 79-86] years and a median estimated glomerular filtration rate of 14 (IQR 11-17) mL/min/1.73 m2 and studied their 5-year outcomes according to the dialysis component of their treatment plans.