Publications by authors named "V Alex Papic"
Article Synopsis
- Parkinson's disease (PD) exhibits a wide range of symptoms, complicating the translation of treatment efficacy from animal models to humans, suggesting that current models may not fully capture all PD characteristics.
- This project investigates whether metabolic dysfunction, induced by administering streptozotocin directly into the striatum of rats, can mimic the symptoms of PD typically seen in patients, focusing on cognitive and motor functions.
- Results showed that rats given streptozotocin bilaterally experienced significant motor and cognitive impairments alongside disrupted brain metabolism, indicating that this method could provide a better animal model for studying PD and testing new therapies.
Video 1 demonstrates the microsurgical resection of petrous apex meningioma. Even small lesions by general rules are regarded as large due to the delicate nature of anatomic localization. The intricate relationship between the tumor and vascular supply of the brainstem and interposition of cranial nerves makes them challenging lesions to resect.
View Article and Find Full Text PDFMicrosurgical resection of meningiomas in a majority of cases leads to a favorable outcome. Therefore, severe postoperative adverse events are less acceptable. The main purpose of this study was to investigate the incidence of symptomatic venous thromboembolism (VTE) and hemorrhagic complications in patients after operative treatment of intracranial meningiomas and to identify the risk factors in this patient subgroup.
View Article and Find Full Text PDFPrimary Intraparenchymal Meningiomas: A Case Report and a Systematic Review.
World Neurosurg
September 2021
Background: Primary intraparenchymal meningiomas are exceedingly rare and often challenging to diagnose, given their misleading radiologic features. It is hypothesized that they arise from the cap cells of the pia mater that enter the brain via penetrating blood vessels during brain development. We systematically reviewed and analyzed previously reported features of primary intraparenchymal meningiomas in terms of radiography, presenting symptoms, and histopathology.
View Article and Find Full Text PDFObjective: Autism Spectrum Disorder is a complex brain disorder and has multiple causes that occur in diverse combinations. There is a need to classify children with ASD at a very young age so that they can access evidence-based intervention that can significantly improve their outcomes.
Case Report: In this report we present a case of autism, which underwent intrathecal autologous bone marrow mononuclear cells transplantation along with neurorehabilitation.