Evaluation of the Italian transport infrastructures: A technical and economic efficiency analysis.

•The deregulation process played a key role in terms of airport efficiency.•The technical efficiency of 32 Italian airports has been evaluated•The methodological approach has been twofold: DEA and Tobit model•The main results show that efficiency is independent of an airport's size.•The findings highlight the decisive role of public shareholders in small airports.

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

Aims/hypothesis: Glucagon-like peptide 1 (GLP-1) is a major incretin, mainly produced by the intestinal L cells, with beneficial actions on pancreatic beta cells. However, while in vivo only very small amounts of GLP-1 reach the pancreas in bioactive form, some observations indicate that GLP-1 may also be produced in the islets. We performed comprehensive morphological, functional and molecular studies to evaluate the presence and various features of a local GLP-1 system in human pancreatic islet cells, including those from type 2 diabetic patients.

Evidence for a role of frataxin in pancreatic islets isolated from multi-organ donors with and without type 2 diabetes mellitus.

Frataxin (FXN) is a mitochondrial protein involved in iron metabolism and in the modulation of reactive oxygen and/or nitrogen species production. No information is currently available as for the role of frataxin in isolated human pancreatic islets. We studied islets from pancreases of multi-organ donors with (T2DM) and without (Ctrl) Type 2 diabetes mellitus.

Direct effects of rapid-acting insulin analogues on insulin signaling in human pancreatic islets in vitro.

Aims: Studies suggest that insulin-signaling molecules are present in the pancreatic islets. For this reason, the effects of insulin glulisine, insulin aspart and regular human insulin (RHI) on the function and molecular features of isolated human pancreatic islets were investigated.

Methods: Human pancreatic islets were prepared by collagenase digestion and density-gradient purification of pancreata from multiple organ donors.