Publications by authors named "V Alemany"
Heart transplantation remains the ultimate treatment strategy for neonates and children with medically refractory end-stage heart failure and utilization of donors after circulatory death (DCD) can expand th donor pool. We have previously shown that mitochondrial transplantation preserves myocardial function and viability in neonatal swine DCD hearts to levels similar to that observed in donation after brain death (DBD). Herein, we sought to investigate the transcriptomic and proteomic pathways implicated in these phenotypic changes using ex situ perfused swine hearts.
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- A 54-year-old woman was admitted with recurrent abdominal pain and new chest pain, leading to the discovery of a thoracic aortic aneurysm, suspected to involve intramural hematoma or aortitis.
- Initial conservative treatment was followed by surgical intervention after imaging suggested intramural hematoma, but surgery revealed severe aortitis without hematoma, indicating complex diagnostic challenges.
- Further examination identified IgG4-related disease linked to chronic lymphocytic leukemia (CLL), highlighting the need for a multidisciplinary approach and various diagnostic methods to accurately assess aortic conditions.
Objective: Heterotaxy syndrome is a complex multisystem abnormality historically associated with high morbidity and mortality. We sought to evaluate the early and long-term outcomes after cardiac surgery in heterotaxy syndrome.
Methods: This is a single-center retrospective review of patients with heterotaxy syndrome undergoing single-ventricle palliation or primary or staged biventricular repair from 1998 to 2018.
The protocol here provides a simple, highly replicable methodology to induce in situ acute regional myocardial ischemia in the rabbit for non-survival and survival experiments. New Zealand White adult rabbit is sedated with atropine, acepromazine, butorphanol, and isoflurane. The animal is intubated and placed on mechanical ventilation.
View Article and Find Full Text PDFObjective: Mitochondrial transplantation has been shown to preserve myocardial function and viability in adult porcine hearts donated after circulatory death (DCD) . Herein, we investigate the efficacy of mitochondrial transplantation for the preservation of myocardial function and viability in neonatal and pediatric porcine DCD heart donation.
Methods: Circulatory death was induced in neonatal and pediatric Yorkshire pigs by cessation of mechanical ventilation.