[Functional-morphologic changes in the gastric and duodenal mucosa during prolonged administration of prednisolone].

A prolonged administration (up to 25 days) of prednisolone to rats (0.4 mg per 100 g of the body mass) reveals some functional-morphological changes in the secretory apparatus and mucin production in the stomach and the duodenum: an increased functional activity of parietal, principle, Ecl- and G-cells of the stomach, Ec-cells and goblet cells of the duodenum (except Ec-cells and goblet cells in the outlet part of the stomach), and by the end of the experiment--hyperplasia of the parietal, G-cells and goblet cells. A conclusion is made that the increased acido-peptic activity of the gastric juice and the erosive-ulcerous complications under a prolonged administration of prednisolone result from an increased functional activity of the fundal glands, G-, Ecl-cells and Ec-cells of the duodenum with a subsequent hyperplasia of the G-cells by the 25th day of the experiment, as well as an insufficient mucin formation in the mucous membrane of the stomach, especially in its outlet part as a consequence of a decreased functional activity of the Ec-cells.

[Functional and morphological status of the gastric mucosa mast cells on the administration of dimedrol and suprastin].

Histochemical and morphometric analysis of mast cells of the gastric and duodenal mucosa of rats given dyphenhydramine and suprastin for a long period of time (up to 45 days) revealed an increase in their functional activity that manifested in the enhancement of the processes of neoformation and maturation of juvenile mast cells and in the increased break down of mature cellular forms.