Publications by authors named "V A Yakimov"
Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreover, it remains elusive how ChP is linked to brain regions associated with peripheral inflammation in SSD.
View Article and Find Full Text PDFBackground: Neonatal herpes simplex virus (HSV) infection is life-threatening, with a mortality of up to 70-80% when disseminated, often due to vague symptoms and delayed treatment. Neonatal screening using dried blood spot (DBS) samples is among the most impactful preventative health measures ever implemented, but screening for HSV has not been investigated.
Methods: We investigated high throughput multiplexed proteomics on DBS samples collected on days 2-3 of life from a nationwide cohort of neonates with HSV infection (n = 53) and matched controls.
Background: Optical coherence tomography and electroretinography studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSDs). However, it remains unclear which specific retinal layers are affected; how the retina, brain, and clinical symptomatology are connected; and how alterations of the visual system are related to genetic disease risk.
Methods: Optical coherence tomography, electroretinography, and brain magnetic resonance imaging were applied to comprehensively investigate the visual system in a cohort of 103 patients with SSDs and 130 healthy control individuals.
Article Synopsis
- - Neuroinflammation and disruption of the blood-cerebrospinal fluid barrier may play significant roles in the development and symptom severity of schizophrenia-spectrum disorders (SSDs), according to a large meta-analysis of first-episode psychosis and recent onset psychotic disorder individuals.
- - Data from 531 individuals showed that while cerebrospinal fluid (CSF) alterations were present in 38.8% of cases, no overall significant link between CSF changes and symptom severity was found; however, males with such alterations had higher positive symptom scores.
- - The study emphasizes that disruption of the blood-cerebrospinal fluid barrier is common in early psychosis and suggests the importance of addressing this disruption along with sex-related differences
Background: There is increasing evidence of immune dysregulation and neuroinflammation occurring in schizophrenia. The aim of this study is to combine studies on routine CSF parameters, as well as cytokines and inflammatory proteins, in individuals with schizophrenia spectrum disorders.
Methods: CSF parameters were summated and inverse variance meta-analyses using a random effects model were performed comparing mean difference or odds ratios.