Publications by authors named "V A Veselovsky"
Article Synopsis
- The study explores using lytic bacteriophages combined with the antibiotic linezolid to treat methicillin-resistant bacteria, showing a strong synergistic effect against planktonic cells.
- A checkerboard assay indicated that a specific combination of low doses of both agents completely inhibited bacterial growth, but the order of treatments affected biofilm cells—sequential treatment was less effective while simultaneous treatment was more beneficial.
- Transcriptomic analysis revealed that the combination altered bacterial metabolism, including energy and virulence factors, emphasizing the need to optimize treatment strategies for maximum effectiveness against infections.
An association between the () intron variant rs521851 and depression symptoms, as measured by the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), has been recently reported. The role of in depression has been linked to disruptions in the gut-brain axis. In this study, we investigated the association between rs521851 and HADS-D scores in an independent cohort of 380 individuals, consisting of 238 patients with an ICD-10 diagnosis of depression and 142 healthy controls.
View Article and Find Full Text PDFAntimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need to monitor the dissemination of antimicrobial resistance genes and understand the mechanisms driving this process. In this study, we analyzed changes to the oropharyngeal and fecal resistomes of patients with COVID-19 undergoing therapy in a hospital setting.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how gut microbiota, particularly commensal bacteria like lactobacilli, interact with the host immune system's cytokines, which are critical in managing inflammation and gut health.
- Using next-generation RNA sequencing, researchers examined the transcriptional responses of lactobacillus strains K32 and R19-3 to various cytokines, revealing significant changes in gene expression linked to metabolism and stress response, especially upon exposure to IL-8 and IL-10.
- The findings highlight a complex adaptation mechanism where these bacteria adjust their gene expression in response to inflammatory signals, paving the way for potential probiotic therapies for conditions like inflammatory bowel disease (IBD).