Patient safety culture through the perspectives of healthcare workers: a longitudinal study in a private healthcare network in Brazil.

Background: Enhancing security and dependability of health systems necessitates resource allocation, a well-defined infrastructure and a steadfast commitment to ensuring its safety and stability over time.

Objective: The aim of this study was to evaluate the temporal trend of patient safety culture according to the perception of professionals working in a private healthcare network in Brazil over a 7-year period (2015-2022).

Methods: The Hospital Survey on Patient Safety Culture questionnaire was distributed to 34 hospitals between 2015 and 2022 with 160 607 responders.

replaces virulence with carbapenem resistance via porin loss.

Pathogenic species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of virulence is limited, hindering the development of new prophylactics and therapeutics targeting infections caused by species. In this study, we assessed the virulence of contemporary clinical isolates in a mouse model of intraperitoneal infection and used comparative genomics to identify genes promoting virulence.

Data-informed selection of evidence-based treatments for posttraumatic stress disorder and co-occurring symptoms.

Posttraumatic stress disorder (PTSD) commonly co-occurs with other disorders. Although there are several evidence-based treatments available for PTSD and co-occurring disorders, including cognitive processing therapy (CPT), prolonged exposure (PE), acceptance and commitment therapy (ACT), and the unified protocol for transdiagnostic treatment of emotional disorders (UP), limited findings clarify the use of baseline symptom data to help providers and patients choose among treatments. To address this, the current study examined baseline symptoms and treatment trajectories among 90 veterans and veteran family members with probable PTSD (based on PCL-5) receiving either trauma-focused (CPT, PE) or transdiagnostic (ACT, UP) treatment via telehealth, with the aim of assisting providers in recognizing patterns to inform data-driven treatment selection.

Deep Brain Stimulation Lead Functional Repositioning After Spontaneous Pneumocephalus Resorption: A Clinical Case Presentation and Systematic Review.

Deep brain stimulation (DBS) has become a critical intervention for managing advanced Parkinson's disease (PD), particularly for patients whose symptoms are no longer controlled by medication. This report details the case of a 61-year-old male with PD who experienced electrode displacement due to pneumocephalus following DBS surgery targeting the subthalamic nucleus (STN). Initial imaging revealed a significant subdural air volume causing electrode displacement.

Does PCR-based pathogen identification reduce mortality in bloodstream infections? Insights from a difference-in-difference analysis.

Background: Bloodstream infections (BSI) are associated with high mortality rates, particularly when caused by resistant pathogens. Reducing the delay in diagnosis and initiation of appropriate treatment is crucial for improving clinical outcomes. The implementation of polymerase chain reaction (PCR) tests in the diagnostic process offers a promising approach to achieving quicker identification of pathogens, thereby potentially reducing mortality associated with BSI.