[1 of the pathways for normalization of populations of malignant cells].

The paper reports reasons for a possibility of tumour regression due to selection of low-malignant and differentiating clones. Experimental evidence is provided supporting this view.

[Heterogeneity of L-line cells in the early stages of clone development].

The clonal study of L cell culture has shown that the clone-forming cells are heterogeneous both in form and in the activities of enzymes (succinate dehydrogenase, lactate dehydrogenase, NAD- and NADP-diaphorase) which were determined by histochemical methods. The morphological heterogeneity is characteristic for clones with not less than 10 cells manifesting itself earlier and heterogeneity as to the activity of the studied enzymes--later, in clones with more than 15-20 cells.

[Effect of fast neutrons on the process of muscle cell differentiation].

A study was made of the effect of fast neutron on differentiation of myoblasts in vitro. The results obtained indicate that irradiation inhibits the differentiation of myoblasts in culture. Irradiation with fast neutrons (1.

[Differentiation and the neoplastic transformation of normal cells].

It is suggested that blastomogenic factors can be considered as the means isolating normal cells from each other. Carcinogenic substances caused cell functions to disturb, to inhibit or to intensify the synthesis of specific substances, to change the cell surface disrupted contacts of interactions between cells, pressing cells to become on the way of evolution, and to create heterogenic populations of cells.