Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child.

Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level.

Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.

Trichodysplasia spinulosa (TS) is a folliculocentric and clinically papular dermatological disorder occurring in the setting of immunosuppression typically in association with solid organ transplantation or hematolymphoid malignancies. We report the occurrence of TS in a 7-year-old girl with Down syndrome and pre-B-acute lymphoblastic leukemia who was completing chemotherapy at onset. The patient's affected follicles were dilated by an expansion of a dystrophic follicular inner root sheath cell population displaying enlarged trichohyaline cytoplasmic granules and progressing centrally to keratotic and parakeratotic debris, and superficially demonstrating some diminutive hair shaft-like material within the keratotic spicules.

Lipoma arborescens of the hip.

Lipoma arborescens is a rare intra-articular lesion characterized by extensive villous proliferation of the synovial membrane and hyperplasia of subsynovial fat. Although it has been described as arising from traumatic, inflammatory, rheumatologic, developmental, and neoplastic causes, its etiology remains unknown. This article describes in detail--for the first time in the orthopedic literature-a case of lipoma arborescens of the hip.

Gastrointestinal autonomic nerve tumors in the pediatric population: a report of four cases and a review of the literature.

Background: Gastrointestinal autonomic nerve tumors (GANTs) are a subpopulation of gastrointestinal stromal tumors (GISTs) that are characterized by ultrastructural features resembling enteric autonomic nerve cells, without epithelial, Schwannian, or smooth muscle differentiation. Delineation of the clinicopathologic features of GANT in the pediatric population is lacking.

Methods: The clinicopathologic and outcome data for four pediatric patients with GANT are presented.