Publications by authors named "V A Rauh"

Background: A large body of data shows that fetal brain development is vulnerable to disruption by air pollution experienced by the mother during pregnancy, adversely affecting cognitive and psychomotor capabilities during childhood (De Asis-Cruz et al., Biol Psychiatry 7:480-90, 2022; Morgan ZEM et al., Environ Health 22:11, 2023).

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  • Low mtDNA copy number (mtDNAcn) in early life has been linked to cognitive decline, but its impact on healthy cognitive development in children is still unclear.
  • The study measured mtDNAcn in umbilical cord blood and child blood at ages 5-7 and analyzed cognitive performance later using standardized tests, finding that both low and high mtDNAcn were associated with poorer cognitive outcomes.
  • Results suggest mtDNAcn may be an important biomarker for assessing neurocognitive performance in children, highlighting the need for further research on mitochondrial markers in healthy populations.
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  • Patients with multiple sclerosis (MS) often face cognitive impairments due to structural disconnections in the brain, affecting how different regions communicate dynamically for normal cognitive function.* -
  • The study analyzed brain imaging data from a cohort of MS patients, categorizing them based on cognitive function and identifying different functional networks involved, such as the visual and default mode networks.* -
  • Cognitively impaired patients showed less frequent transitions between brain connectivity states and required more energy to make these transitions, suggesting that their brains struggle to adapt functionally compared to cognitively preserved patients.*
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During processing and storage of both conventional and lactose-hydrolyzed UHT milk (LHM), aggregation of milk proteins occurs. Protein aggregation can inter alia occur via nonreducible covalent cross-links derived from either Maillard or dehydroalanine (DHA) pathways. To study this further in relation to processing method and lactase enzyme purity, LHM was produced using 3 different lactase preparations, with lactase enzymes added in a dairy setting either before (prehydrolysis) or after (posthydrolysis) UHT treatment.

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Background: Parental psychological distress is a well-known risk factor for developmental psychopathology, with longer term parental distress associated with worse youth mental health. Neurotoxicant exposure during pregnancy is a risk factor for both poor maternal and youth mental health. The impact of one class of pollutant, polycyclic aromatic hydrocarbons (PAH), on long-term trajectories of maternal distress and youth self-reported mental health symptoms in adolescence has been understudied.

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