[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg].

In 32 patients with primary congenital glaucoma (PCG), a search for mutations in the myocilin (MYOC), cytochrome P450B1 (CYP1B1), and WDR36 genes was performed. The Q368X mutation in myocilin gene, typical of the patients with adult-onset primary open-angle glaucoma (POAG), was not detected in the PCG patients. Screening of the CYP1B1 introns 2 and 3 for the presence of mutations in PCG patients revealed only six DNA polymorphisms, including IVS1-12ntT>C (g.

[Mutations and polymorphisms in the genes for myocilin and optineur in as the risk factors of primary open-angle glaucoma].

A collection of DNA samples obtained from primary open-angle glaucoma (POAG) patients from St. Petersburg was analyzed for single-strand conformation polymorphism (SSCP) to reveal sequence variants in exon 3 of the myocilin gene (MYOC/TIGR) and in exons 4 and 5 of the optineurin gene (OPTN), where most of the mutations revealed worldwide are located. The Q368X mutation (c.

[Organization of therapy and rehabilitation of patients with sensorineural hearing disorders in the psychotherapeutic neurological center].

In 1979, a psychotherapeutic surdoneurological center consisting of an outpatient department and a 60-bed hospital was opened in the city of Dnepropetrovsk. The responsibility of the center is to render social and rehabilitation aid to patients with hearing loss of sensorineural origin. Rehabilitation procedures include non-drug therapy, psychotherapy, physical therapy, acupuncture and reflexotherapy, surdopedagogical lessons in the alert and hypnotic state, special talks to exclude discomfortable sensations, both of psychological and hearing type, related to the use of hearing aids.