[Arthroscopic Subtalar Distraction Arthrodesis in Post-Traumatic Indications].

Purpose Of The Study: This manuscript aims to present the method of arthroscopic assisted subtalar arthrodesis and to evaluate the benefi ts of this surgery on our study population.

Material And Methods: In the period from 9/2007 to 1/2020, a total of 33 subtalar arthrodesis were performed in 31 patients aged 19-66 years (mean 48 years, median 50 years). The indication for arthrodesis was subtalar arthritis causing pain and gait disorders, or hindfoot deformities (most commonly after a calcaneus bone fracture).

Fractionated Radiosurgical Treatment of Intracerebral Schwannoma: A Case Report and Literature Review.

Intracranial schwannomas (ICS) unrelated to the cranial nerves are extremely rare; around 70 cases have been reported worldwide. The available literature consists of case reports and small series that present variable characteristics distinguishing these lesions. Brain parenchyma schwannomas are typically benign tumors with currently unknown origins.

Synthetic Lethality - Its Current Application and Potential in Oncological Treatment.

Background: Synthetic lethality is a gene interaction where a defect in one of the interacting genes is compatible with cell viability, whereas the disruption of both genes leads to cell death. The discovery of the lethal effect of poly(ADP-ribose) polymerase (PARP) inhibitors in BRCA1/2 mutant cells has opened an important direction in the development of targeted therapy in oncology. The PARP inhibitor olaparib has become the first registered drug for recurrent high-grade serous ovarian cancer treatment based on synthetic lethality that has reached the clinic.