[Pharmacologic analysis of the free radical mechanism of poisoning-induced memory disorders].

Ethylene glycol, the pyrethroid pesticide deltametrin, and the m-cholinolytics atropine and scopolamine disturb the formation and storage of signs of memory in rats appraised in the test for conditional reaction of passive and active avoidance. The antioxidants alpha-tocopherol and sodium selenite, the nootropic agent piracetam, and the amino acid L-tryptophan prevent amnesia. Spectrometry of optic density in a "diphenylpicrylhydrazil-drug" model system showed the existence of anti-radical activity in piracetam and L-tryptophan.