Publications by authors named "V A Pisareva"

This paper briefly reviews the results of scientific research on the proton conductivity of sulfonated polyphenylquinoxalines. Synthesis, structure (IR spectroscopy, SEM, quantum-chemical modeling, molecular weight distribution), moisture capacity, thermal properties, and proton conductivity of sulfonated polyphenylquinoxalines (sulfur content 2.6, 4.

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Schlafen 14 (SLFN14) has recently been identified as an endoribonuclease responsible for cleaving RNA to regulate and inhibit protein synthesis. Early studies revealed that members of the SLFN family are capable of altering lineage commitment during T-cell differentiation by using cell-cycle arrest as a means of translational control by RNase activity. SLFN14 has been reported as a novel gene causing an inherited macrothrombocytopenia and bleeding in human patients; however, the role of this endoribonuclease in megakaryopoiesis and thrombopoiesis remains unknown.

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Article Synopsis
  • Viruses manipulate cellular machinery for protein production, primarily by targeting the initiation stage of translation through strategies like cellular mimicry and ribosome hijacking.
  • A study utilized electron cryo-microscopy and translation assays to analyze a novel internal ribosomal entry site (IRES) in viral RNA, which forms a functional initiation complex using a specific intermediate.
  • The research highlights a unique multi-domain structure of the IRES that interacts closely with the ribosome, emphasizing the significance of 5'-UTR regions in translation regulation and the potential diversity of viral IRESs.
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Co-opting the cellular machinery for protein production is a compulsory requirement for viruses. The Cricket Paralysis Virus employs an Internal Ribosomal Entry Site (CrPV-IRES) to express its structural genes in the late stage of infection. Ribosome hijacking is achieved by a sophisticated use of molecular mimicry to tRNA and mRNA, employed to manipulate intrinsically dynamic components of the ribosome.

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