Publications by authors named "V A Pellegrino"
A critical factor in thrombus formation during venoarterial extracorporeal membrane oxygenation (VA ECMO) is prothrombotic flow dynamics generated by the drainage cannula's design. This study aimed to create and evaluate a novel drainage cannula design which optimized blood flow dynamics to reduce thrombus formation. Computational fluid dynamics (CFD) was used to iteratively vary drainage cannula design parameters such as inner wall shape and side hole shape.
View Article and Find Full Text PDFThis study aimed to describe the population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify dosing regimens with a high likelihood of achieving effective exposures. Serial blood samples were collected over a single-dosing interval during ECMO. Total plasma concentrations were measured by a validated chromatographic assay.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the effects of conservative versus liberal oxygen strategies on patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the ICU, aiming to find a balance between avoiding hyperoxia and preventing hypoxia.
- A total of 300 patients were randomly assigned to either conservative (target SaO 92-96%) or liberal oxygen (target SaO 97-100%), but both groups showed similar outcomes in ICU-free days and mortality rates at days 28 and 60.
- The conservative group had significantly more major protocol deviations compared to the liberal group, but overall, the two oxygen strategies did not differ in their impact on patient recovery in the ICU.