[Clinico-morphological features of endometrioid disease: adenomyosis, ovarian endometriosis, extragenital endometriosis].

Adenomyosis, ovarian endometriosis and extragenital endometriosis are clinico-pathologic types of one nosologic form as endometrioid disease (ED). ED's clinical presentations are various, but they are essentially characterized by a pain syndrome and disorder of menstrual cycle. The comparative clinico-pathologic analysis of adenomyosis, ovarian endometriosis, and extragenital endometriosis affords to suppose that theirs clinical course, the intensity and character of symptoms, as well as morphogenetic processes are generally determined by the organ localization.

[Cancer transformation of adenomyosis].

Adenomyosis cancerous transformation (AMCT) was observed in a 48-year old female without cancer of the endometrium. Various forms of transformation (stages of AMCT morphogensis) in and outside of denomyosis (AM) foci are described (adenomatosis, invasive cancer, metastases). AMCT diagnosis requires histologic examination of the surgical material with establishing multicentric tumor transformation of AM foci at different stages of morphogenesis.

[Combination of uterine adenomyosis with leiomyoma].

A morphological analysis of 50 cases of adenomyosis (AM) and 150 cases of AM combination with leiomyoma (LM) with regard to their morphofunctional and histotopographical interrelations was performed. The asynchronous character and mosaicism of estrogen/progesteron receptors expression in the gland epithelium and AM stromal cells of one patient was established immunohistochemically. This probably determines uneffective hormonal therapy of AM patients.