BECN1 protein expression is associated with poor survival in triple negative locally advanced breast cancer.

Objective: The role that Beclin 1 (BECN1) plays in the development and progression of cancer mediated by autophagy, as well as its differential expression in breast cancer cell lines and mammary tumor tissue according to the molecular subtype, has been demonstrated. The objective of this study was to evaluate the association of BECN1 cytoplasmic expression with clinical and pathologic response, recurrence, disease-free survival (DFS) and overall survival (OS) in patients with locally advanced breast cancer (LABC), according to immunophenotype.

Patients And Methods: 64 patients with non-triple negative LABC and 20 patients with triple negative LABC who received preoperative chemotherapy were included in an observational, analytical and retrospective study to evaluate the cytoplasmic expression of BECN1 protein by immunohistochemistry in microarrays of breast cancer tissue obtained before treatment.

Efecto de la frecuencia de aplicación de estrógenos locales sobre el grosor endometrial en mujeres posmenopáusicas.

Introduction: Conjugated estrogens, when used by the vaginal route for the relief of vaginal dryness and atrophy, can produce endometrial changes.

Objective: To know the effect of vaginal conjugated estrogens application frequency on endometrial thickness in postmenopausal women.

Method: Seventy postmenopausal women with vaginal dryness who received conjugated estrogen cream (0.

[Concordance between preoperative and definitive study in endometrial cancer].

Background: Some studies have been realized to know the concordance level between the preoperative and the diagnosis of endometrial cancer and it has been observed that there is a tendency to undergrade the stage of cancer in preoperative studies.

Methods: It was carried out an observational, retrolective, transversal and comparative study to establish the concordance between the preoperative and the definitive study in endometrial cancer. We revised the records of the Pathology department of the Hospital "Luis Castelazo Ayala" from January 1st, 2012, to December 31th, 2014.

[Association of ovarian tumors with CA-125].

Background: The tumor marker CA-125 is the most widely used serum marker for ovarian cancer screening. The aim of this paper was to establish the association between histopathologic result of ovarian tumors with serologic CA-125 and utility for the diagnosis of ovarian tumors at a Ginecoobstetric hospital.

Methods: An observational, retrospective, descriptive and longitudinal study, from September 1st 2010 to February 28 2013.