Epithelioid hemangioma of the orbit.

Objective: To describe the histopathologic features of two cases of epithelioid hemangioma occurring in the orbit and to distinguish this condition from Kimura's disease and from other vascular lesions of proliferated endothelium.

Design: Two interventional case reports.

Intervention: Treatment consisted of orbitotomy with excision of the tumor.

Association of cisplatin nephrotoxicity with patient characteristics and cisplatin administration methods.

Objective: To assess factors that affect cisplatin nephrotoxicity.

Methods: In 425 patients treated with cisplatin, we assessed the effect of pretreatment factors and treatment conditions on the rise in serum creatinine with the first course of cisplatin, on the maximum rise in serum creatinine over the entire course of the cisplatin therapy, and on residual nephrotoxicity after the last cisplatin treatment ended. (Because of the nature of the relationship between serum creatinine and creatinine clearance, rise in serum creatinine was divided by pretreatment creatinine squared.

Factors affecting platinum concentrations in human surgical tumour specimens after cisplatin.

We assessed factors which affect cisplatin concentrations in human surgical tumour specimens. Cisplatin 10 mg m-2 was given i.v.

Cisplatin and radiation in the treatment of tumors of the central nervous system: pharmacological considerations and results of early studies.

Purpose: To review the human central nervous system pharmacology of cisplatin, factors that affect cisplatin uptake in tumors, and use alone and with radiation for the treatment of primary brain tumors.

Methods And Materials: The authors review their own prior published and unpublished experience and data published by other groups on the above issues.

Results: Cisplatin is one of the most active chemotherapy drugs available for the treatment of solid tumors.

Factors affecting human autopsy kidney-cortex and kidney-medulla platinum concentrations after cisplatin administration.

The objective of this study was to determine factors that affect cisplatin concentrations in human kidney cortex. We used flameless atomic absorption spectrophotometry to assay platinum in autopsy specimens of kidney cortex obtained from 83 cisplatin-treated patients. Concentrations were correlated with pretreatment factors and treatment conditions using univariate nonparametric statistics.